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Wenyao Zhen

Research Fellow

Wenyao Zhen

Notable Publications in past 5 years:

1.Wenyao Zhen, Xiaomin Jiang, En Li, Tomas Germanas, Morten J. Lee, Taokun Luo, Xin Ma, Chaoyu Wang, Yimei Chen, Ralph R. Weichselbaum*, Wenbin Lin*. Transforming Malignant Tumors into Vulnerable Phenotypes via Nanoscale Coordination Polymer Mediated Cell Senescence and Photodynamic Therapy. Biomaterials 2025, doi: 10.1016/j.biomaterials.2025.123355. (IF=12.8)

2.Wenyao Zhen, Ziwan Xu, Yibin Mao, Caroline McCleary, Xiaomin Jiang, Ralph R. Weichselbaum*, Wenbin Lin*. Nanoscale mixed-ligand metal-organic framework for X-ray stimulated cancer therapy. J. Am. Chem. Soc. 2024, 146, 146, 33149-33158. (IF=14.4)

3.Wenyao Zhen, Dong Won Kang, Yingjie Fan, Zitong Wang, Tomas Germanas, Geoffrey T. Nash, Qijie Shen, Rachel Leech, Jinhong Li, Gregory S. Engel, Ralph R. Weichselbaum, Wenbin Lin*. Simultaneous protonation and metalation of a porphyrin covalent organic framework enhance photodynamic therapy. J. Am. Chem. Soc. 2024, 146, 16609-16618. (IF=14.4)

4.Ziwan Xu‡, Wenyao Zhen‡, Caroline McCleary, Taokun Luo, Xiaomin Jiang, Cheng Peng, Ralph R. Weichselbaum, Wenbin Lin*. Nanoscale metal-organic framework with an X-ray triggerable prodrug for synergistic radiotherapy and chemotherapy, J. Am. Chem. Soc. 2023, 145, 18698-18704. (IF=14.4)

5.Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin*. Digitonin-loaded nanoscale metal-organic framework for mitochondria-targeted radiotherapy-radiodynamic therapy and disulfidptosis, Adv. Mater. 2024, 2405494. (IF=27.4)

6.Wenyao Zhen, Ralph R. Weichselbaum,* Wenbin Lin*. Nanoparticle‐mediated radiotherapy remodels the tumor microenvironment to enhance antitumor efficacy, Adv. Mater. 2022, 2206370. (IF=27.4)

7.Wenyao Zhen, Shangjie An, Shuqi Wang, Wenxue Hu, Yujie Li, Xiue Jiang*, Jinghong Li*. Precise subcellular organelle targeting for boosting endogenous-stimuli-mediated tumor therapy, Adv. Mater. 2021, 2101572. (IF=27.4)

8.Wenyao Zhen, Tomas Germanas, Ralph R. Weichselbaum, Wenbin Lin*, Multifunctional nanomaterials mediate cholesterol depletion for cancer treatment, Angew. Chem. Int. Ed. 2024, 136, e202412844. (IF=16.1)

9.Wenyao Zhen, Yang Liu, Shangjie An, Xiue Jiang*. Glutathione‐induced in situ michael addition between nanoparticles for pyroptosis and immunotherapy, Angew. Chem. Int. Ed. 2023, 62, 2301866. (IF=16.1)

10.Wenyao Zhen, Yang Liu, Wei Wang, Prof. Mengchao Zhang, Wenxue Hu, Xiaodan Jia, Chao Wang, Xiue Jiang*. Specific "unlocking" of a nanozyme-based butterfly effect to break the evolutionary fitness of chaotic tumors, Angew. Chem. Int. Ed. 2020, 59, 9491-9497. (IF=16.1)



Selected Honors & Scholarships

Apr. 2023

2022 CHAMBROAD Technology Award, Chinese Chemical Society, Shandong Yingbo Group Co., Ltd.

Feb. 2023

First Prize of the CAIA Award for Scientific and Technological Achievements from the China Association for Analysis and Testing

June 2021

Outstanding Graduate of Anhui Province's General Higher Education Institutions, Anhui Provincial Department of Education, Anhui Provincial Department of Human Resources and Social Security

Jul. 2021

Special Prize of President Scholarship for Postgraduate Students, Chinese Academy of Sciences

June 2021

Doctoral Thesis Excellence Support Program, University of Science and Technology of China

Nov. 2020

Oxford Instrument Rising Star Scholarship, University of Science and Technology of China, Oxford Instruments Technology (Shanghai) Co., Ltd.

Sep. 2020

National Scholarship (top 5‰), Ministry of Education of China

Feb. 2020

Be selected to participate in the 70th Lindau Nobel Laureate Meetings taking place in Lindau, Germany. (there are 30 Chinese students with interdisciplinary background can be selected every two years)

Oct. 2018

National Scholarship (top 5‰), Ministry of Education of China

 

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Questions?
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Yong Loo Lin School of Medicine National University of Singapore

Department of Diagnostic Radiology

National University Hospital, 

Main Building, Lobby F, Level 4

#04-398, DDI Library

5 Lower Kent Ridge Road

Singapore 119074

j.zhang@nus.edu.sg

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