
Wenyao Zhen
Research Fellow

Notable Publications in past 5 years:
1.Wenyao Zhen, Xiaomin Jiang, En Li, Tomas Germanas, Morten J. Lee, Taokun Luo, Xin Ma, Chaoyu Wang, Yimei Chen, Ralph R. Weichselbaum*, Wenbin Lin*. Transforming Malignant Tumors into Vulnerable Phenotypes via Nanoscale Coordination Polymer Mediated Cell Senescence and Photodynamic Therapy. Biomaterials 2025, doi: 10.1016/j.biomaterials.2025.123355. (IF=12.8)
2.Wenyao Zhen, Ziwan Xu, Yibin Mao, Caroline McCleary, Xiaomin Jiang, Ralph R. Weichselbaum*, Wenbin Lin*. Nanoscale mixed-ligand metal-organic framework for X-ray stimulated cancer therapy. J. Am. Chem. Soc. 2024, 146, 146, 33149-33158. (IF=14.4)
3.Wenyao Zhen, Dong Won Kang, Yingjie Fan, Zitong Wang, Tomas Germanas, Geoffrey T. Nash, Qijie Shen, Rachel Leech, Jinhong Li, Gregory S. Engel, Ralph R. Weichselbaum, Wenbin Lin*. Simultaneous protonation and metalation of a porphyrin covalent organic framework enhance photodynamic therapy. J. Am. Chem. Soc. 2024, 146, 16609-16618. (IF=14.4)
4.Ziwan Xu‡, Wenyao Zhen‡, Caroline McCleary, Taokun Luo, Xiaomin Jiang, Cheng Peng, Ralph R. Weichselbaum, Wenbin Lin*. Nanoscale metal-organic framework with an X-ray triggerable prodrug for synergistic radiotherapy and chemotherapy, J. Am. Chem. Soc. 2023, 145, 18698-18704. (IF=14.4)
5.Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin*. Digitonin-loaded nanoscale metal-organic framework for mitochondria-targeted radiotherapy-radiodynamic therapy and disulfidptosis, Adv. Mater. 2024, 2405494. (IF=27.4)
6.Wenyao Zhen, Ralph R. Weichselbaum,* Wenbin Lin*. Nanoparticle‐mediated radiotherapy remodels the tumor microenvironment to enhance antitumor efficacy, Adv. Mater. 2022, 2206370. (IF=27.4)
7.Wenyao Zhen, Shangjie An, Shuqi Wang, Wenxue Hu, Yujie Li, Xiue Jiang*, Jinghong Li*. Precise subcellular organelle targeting for boosting endogenous-stimuli-mediated tumor therapy, Adv. Mater. 2021, 2101572. (IF=27.4)
8.Wenyao Zhen, Tomas Germanas, Ralph R. Weichselbaum, Wenbin Lin*, Multifunctional nanomaterials mediate cholesterol depletion for cancer treatment, Angew. Chem. Int. Ed. 2024, 136, e202412844. (IF=16.1)
9.Wenyao Zhen, Yang Liu, Shangjie An, Xiue Jiang*. Glutathione‐induced in situ michael addition between nanoparticles for pyroptosis and immunotherapy, Angew. Chem. Int. Ed. 2023, 62, 2301866. (IF=16.1)
10.Wenyao Zhen, Yang Liu, Wei Wang, Prof. Mengchao Zhang, Wenxue Hu, Xiaodan Jia, Chao Wang, Xiue Jiang*. Specific "unlocking" of a nanozyme-based butterfly effect to break the evolutionary fitness of chaotic tumors, Angew. Chem. Int. Ed. 2020, 59, 9491-9497. (IF=16.1)
Selected Honors & Scholarships
Apr. 2023 | 2022 CHAMBROAD Technology Award, Chinese Chemical Society, Shandong Yingbo Group Co., Ltd. |
Feb. 2023 | First Prize of the CAIA Award for Scientific and Technological Achievements from the China Association for Analysis and Testing |
June 2021 | Outstanding Graduate of Anhui Province's General Higher Education Institutions, Anhui Provincial Department of Education, Anhui Provincial Department of Human Resources and Social Security |
Jul. 2021 | Special Prize of President Scholarship for Postgraduate Students, Chinese Academy of Sciences |
June 2021 | Doctoral Thesis Excellence Support Program, University of Science and Technology of China |
Nov. 2020 | Oxford Instrument Rising Star Scholarship, University of Science and Technology of China, Oxford Instruments Technology (Shanghai) Co., Ltd. |
Sep. 2020 | National Scholarship (top 5‰), Ministry of Education of China |
Feb. 2020 | Be selected to participate in the 70th Lindau Nobel Laureate Meetings taking place in Lindau, Germany. (there are 30 Chinese students with interdisciplinary background can be selected every two years) |
Oct. 2018 | National Scholarship (top 5‰), Ministry of Education of China |