Wenyao Zhen

Notable Publications:

1.Wenyao Zhen‡, Ziwan Xu‡, Yibin Mao, Caroline McCleary, Xiaomin Jiang, Ralph R. Weichselbaum*, Wenbin Lin*. Nanoscale mixed-ligand metal-organic framework for X-ray stimulated cancer therapy. J. Am. Chem. Soc. 2024, 146, 146, 33149-33158. (IF=14.4)

2.Wenyao Zhen‡, Dong Won Kang‡, Yingjie Fan, Zitong Wang, Tomas Germanas, Geoffrey T. Nash, Qijie Shen, Rachel Leech, Jinhong Li, Gregory S. Engel, Ralph R. Weichselbaum, Wenbin Lin*. Simultaneous protonation and metalation of a porphyrin covalent organic framework enhance photodynamic therapy. J. Am. Chem. Soc. 2024, 146, 16609-16618. (IF=14.4)

3.Ziwan Xu‡, Wenyao Zhen‡, Caroline McCleary, Taokun Luo, Xiaomin Jiang, Cheng Peng, Ralph R. Weichselbaum, Wenbin Lin*. Nanoscale metal-organic framework with an X-ray triggerable prodrug for synergistic radiotherapy and chemotherapy, J. Am. Chem. Soc. 2023, 145, 18698-18704. (IF=14.4)

4.Wenyao Zhen‡, Yingjie Fan‡, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin*. Digitonin-loaded nanoscale metal-organic framework for mitochondria-targeted radiotherapy-radiodynamic therapy and disulfidptosis, Adv. Mater. 2024, 2405494. (IF=27.4)

5.Wenyao Zhen, Ralph R. Weichselbaum,* Wenbin Lin*. Nanoparticle‐mediated radiotherapy remodels the tumor microenvironment to enhance antitumor efficacy, Adv. Mater. 2022, 2206370. (IF=27.4)

6.Wenyao Zhen, Shangjie An, Shuqi Wang, Wenxue Hu, Yujie Li, Xiue Jiang*, Jinghong Li*. Precise subcellular organelle targeting for boosting endogenous-stimuli-mediated tumor therapy, Adv. Mater. 2021, 2101572. (IF=27.4)

7.Wenyao Zhen, Tomas Germanas, Ralph R. Weichselbaum, Wenbin Lin*, Multifunctional nanomaterials mediate cholesterol depletion for cancer treatment, Angew. Chem. Int. Ed. 2024, 136, e202412844. (IF=16.1)

8.Wenyao Zhen, Yang Liu, Shangjie An, Xiue Jiang*. Glutathione‐induced in situ michael addition between nanoparticles for pyroptosis and immunotherapy, Angew. Chem. Int. Ed. 2023, 62, 2301866. (IF=16.1)

9.Wenyao Zhen, Yang Liu, Wei Wang, Prof. Mengchao Zhang, Wenxue Hu, Xiaodan Jia, Chao Wang, Xiue Jiang*. Specific "unlocking" of a nanozyme-based butterfly effect to break the evolutionary fitness of chaotic tumors, Angew. Chem. Int. Ed. 2020, 59, 9491-9497. (IF=16.1)

10.Wenyao Zhen, Yang Liu, Lin Lin, Jing Bai, Xiaodan Jia, Huayu Tian*, Xiue Jiang*. BSA‐IrO2: catalase‐like nanoparticles with high photothermal conversion efficiency and a high X‐ray absorption coefficient for anti‐inflammation and antitumor theranostics, Angew. Chem. Int. Ed. 2018, 57, 10309-10313. (IF=16.1)

11.Wenyao Zhen, Yang Liu, Mengchao Zhang, Wenxue Hu, Wei Wang, Xiaodan Jia, Xiue Jiang*. Multi-caged IrOx for facile preparation of "six-in-one" nanoagent for subcutaneous and lymphatic tumors inhibition against recurrence and metastasis, Adv. Funct. Mater. 2020, 30, 2002274. (IF=18.5)

12.Wenyao Zhen,‡ Taokun Luo,‡ Zitong Wang, Xiaomin Jiang, Eric Yuan, Ralph R. Weichselbaum, Wenbin Lin*. Mechanoregulatory cholesterol oxidase-functionalized nanoscale metal-organic framework stimulates pyroptosis and reinvigorates T cells, Small 2023, 19, 2305440. (IF=13)

13.Wenyao Zhen, Xiaoyuan Chen*. Inflammasome-activating nanovaccine for cancer immunotherapy, Cancer Res. 2024, 84, 3709. (IF=12.5)

14.Wenyao Zhen, Yang Liu, Xiaodan Jia, Lie Wu, Chao Wang, Xiue Jiang*. Reductive surfactant-assisted one-step fabrication of a BiOI/BiOIO3 heterojunction biophotocatalyst for enhanced photodynamic theranostics overcoming tumor hypoxia, Nanoscale Horiz. 2019, 4, 720-726. (IF=8)

15.Wenyao Zhen,  Shangjie An, Wei Wang, Yang Liu, Xiaodan Jia, Chao Wang, Mengchao Zhang, Xiue Jiang*. Gram-scale fabrication of Bi@C nanoparticles through one-step hydrothermal method for dual-model imaging-guided NIR-II photothermal therapy, Nanoscale 2019, 11, 9906-9911. (IF=5.8)

16.Wenyao Zhen, Wenxue Hu, Liang Dong, Shangjie An, Xiue Jiang*. Nanomaterials for regulation of tumor microenvironment and theranostics, Nanoscale Adv. 2020, 2, 1395-1409. (IF=4.6)

17.Wenyao Zhen, Wei Wang, Zhifang Ma, Jing Bai, Xiaodan Jia, Yudi Ruan, Chao Wang, Mengchao Zhang*, Xiue Jiang*. Multienzyme‐mimicking nanocomposite for tumor phototheranostics and normal cell protection, ChemNanoMat 2019, 1, 101-109. (IF=2.6)

Patents

1. Prof. Jiang, X.; Zhen, W.; An, S.; Jia, X.; Wang, C. A BSA-Fe Spray Assisted New Mechanism of Wound Healing by Promoting the Growth of Fibroblasts. Chinese Patent, Application No. 201910668914.8, 2019.

2. Prof. Jiang, X.; Zhen, W.; Jia, X.; Exploration and application of a bovine Serum Albumin-Tea Polyphenols-Metal nanocomplex. Chinese Patent, Application No. 202011594532.4, 2020.

3. Jiang, X.; Prof. Lin, W.; Xu, Z.; Zhen, W. Nanoscale metal organic frameworks with X-ray triggerable prodrugs for combination radiotherapy, chemotherapy and immunotherapy. The US patent, Application No. UCHI 23-T-193.

Honors & Scholarships